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Brian Ross, Ph.D.

Professor, Biological Chemistry




Research Profile

Molecular imaging is rapidly emerging as an exciting area of multidisciplinary research that allows physiology and molecular processes to be visualized in living tissue. Instrumentation involved in molecular imaging includes magnetic resonance imaging and spectroscopy (MRI/S), bioluminescence imaging, positron emission tomography (PET) and x-ray computer assisted tomography (CAT). As part of a Molecular Imaging Center here at the University of Michigan, we are currently using these various imaging modalities to investigate cancer growth and response to traditional and emerging therapies including gene therapy. In addition, we are in the process of developing several novel molecular reporter constructs which when used in combination with imaging techniques, will provide noninvasive measures of specific molecular events occurring in living tissue. We anticipate that these approaches will be used for both in vivo tumor studies and for applications in transgenic mice as well.

Awards

1987 -- 1990 Research Fellowship from the Association for BrainTumor Research.
1998 Invited Plenary Lecture at the First International Meeting of Gene Imaging, Greece.
1998 Invited Plenary Lecture at the Second International Meeting of Gene Imaging, Greece.
2004 Chandran Lecture at Duke U, NC

Publications

Chenevert, T.L., McKeever, P.E. and Ross, B.D. (1997) Monitoring Early Response of Experimental Brain Tumors to Therapy Using Diffusion MRI. Clinical Cancer Research 3, 1457-1466.

Ross, B.D., Zhao, Y.J., Neal, E.R., Stegman, L.D., Ercolani, M., Ben-Yoseph, O. and Chenevert, T.L. (1998) Contributions of Cell Kill and Post-Treatment Tumor Growth Rates to the Repopulation of Intracerebral 9L Tumors After Chemotherapy: An MRI Study. Proc. Natl. Acad. Sci. 95(12), 7012-7017.

Stegman, L.D., Rehemtulla, A., Beattie, B., Kievit, E., Lawrence, T.S., Blasberg, R.G., Tjuvajev, J.G. and Ross, B.D. (1999) Noninvasive Quantitation of Cytosine Deaminase Transgene Expression in Human Tumor Xenografts In Vivo with Magnetic Resonance Spectroscopy. Proc. Natl. Acad. Sci. 96, 9821-9826.

Evelhoch, J.L., Gillies, R.J., Karczmar, G.S., Koutcher, J.A., Maxwell, R.J., Nalcioglu, O., Raghunand, N., Ronen, S.M., Ross, B.D. and Swartz, H.M. (2000) Applications of Magnetic Resonance in Models Systems: Cancer Therapeutics. Neoplasia 2, 153-166.

Chinnaiyan, A.M., Prasad, U., Shankar, S., Hamstra, D.A., Shanaiah, M., Chenevert, T.L., Ross, B.D. and Rehemtulla, A. (2000) Combined Effect of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand and Ionizing Radiation in Breast Cancer Therapy. Proc. Natl. Acad. Sci., In press. PMID: 10677530

bdross@umich.edu

Office: 2071 BSRB, Box 220
PH: (734)763-2099

PubMed: ross bd

Department Affiliations

Medical School
Radiology Department