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Biological Chemistry Seminar Series 2010-2011


Date Name Title Faculty Host

08//06/10

Jay N. Pieczynski, Ph.D. Candidate, Department of Biological Chemistry, University of Michigan Medical School
Mentor: Dr. Benjamin L. Margolis

Regulation of Apical Polarity Complexes

Dissertation Defense

09/07/10

Squire J. Booker, Penn State

Molecular Cannibalism as an Enzymatic Strategy for C-H Bond Activation via Sulfur Insertion: The Biosynthesis of Lipoic Acid

Seminar

09/14/10

Pamela Stanley, Professor of Cell Biology, Albert Einstein College of Medicine

Regulation of Notch Signaling by Glycans during Embryogenesis and T Cell Development

Irwin J. Goldstein Lectureship in Glycobiology

09/16/10

Sean Ferris, Ph.D. Candidate, Department of Biological Chemistry, University of Michigan Medical School

The Role of the UDP-Glucose:Glycoprotein Glucosyltransferase (GT1) in Glycoprotein Folding and Trafficking

Graduate Seminar

09/21/10

Eva Nogales, UC Berkeley

Microtubule-kinetochore interactions

Seminar

09/23/10

Shelley Berger, University of Pennsylvania

Histone Covalent Modifications in Epigenetic Regulation

Epigenetic Mechanisms in Transcription and Disease Symposium

09/23/10

Arul Chinnaiyan, Departments of Pathology and Urology, University of Michigan

Targeting Epigenetic Pathways in Cancer

Epigenetic Mechanisms in Transcription and Disease Symposium

09/23/10

Sharon Dent, University of Texas, MD Anderson Cancer Center

Secret Lives of Histone Modifiers

Epigenetic Mechanisms in Transcription and Disease Symposium

09/23/10

Robert Roeder, Rockefeller University

Function of Diverse Transcriptional Coactivators in Animal Cells

Epigenetic Mechanisms in Transcription and Disease Symposium

09/23/10

Ali Shilatifard, Stowers Institute for Medical Research

The Super Elongation Complex (SEC) and the Molecular Mechanism for MLL-Based Leukemogenesis

Epigenetic Mechanisms in Transcription and Disease Symposium

09/23/10

Harinder Singh, Genentech, Inc.

DNA Sequence-directed Compartmentalization and Silencing of Chromatin Domains at the Nuclear Laminas

Epigenetic Mechanisms in Transcription and Disease Symposium

09/23/10

Raymond Trievel, Depatrment of Biological Chemistry, University of Michigan

Structural Biochemistry of
Histone Methylation

Epigenetic Mechanisms in Transcription and Disease Symposium

09/28/10

Jeff Coller, Case Western Reserve University

Decapping of non-coding and coding RNAs is a critical node in gene express

Seminar

10/05/10

Cathy Smith

Histone Deactylases as Coactivators in Glucocorticoid- regulated Transcription

Seminar

10/06/10

Alex Ninfa, Professor of Biological Chemistry, University of Michigan

Limits of Modularity of Cellular Signaling Systems

CCMB/Bioinformatics Seminar Series

10/07/10

Mark Taylor, Ph.D. Candidate, Department of Biological Chemistry, University of Michigan Medical School

Histone Deactylases as Coactivators in Glucocorticoid- regulated Transcription

711 Graduate Seminar

10/12/10

Brian Fox, University of Wisconsin

A Structure-enabled Tour of the Diiron Monoxygenase Active Site and Reaction

Seminar

10/14/10

Claudia McDonald, Ph.D. Candidate, Department of Biological Chemistry, University of Michigan Medical School

An unusual mechanism of thymidylate biosynthesis in organisms containing the thyX gene

711 Graduate Seminar

10/19/10

Sepideh Khorasanizadeh, University of Virginia

Functions of Chromodomains in Epigenetic Regulations

Seminar

10//21/10

Zhonghua Yan, Ph.D. Candidate, Department of Biological Chemistry, University of Michigan Medical School
Mentor: Dr. Ruma Banerjee

Thiol-Mediated Redox Modulation of the Adaptive Immune Response

Dissertation Defense

10/26/10

Kevin Redding, Arizona State University

Mapping out intra-protein electron transfer pathways within Photosystem I via a combination of genetics and spectroscopy

Seminar

10/28/10

Michael Lofgren, Ph.D. Candidate, Department of Biological Chemistry, University of Michigan Medical School

Mitochondrial Processing and Trafficking of Coenzyme-B12

Graduate Seminar

11/02/10

Ileana Cristea, Princeton University

At the Dynamic Interface between Viruses and Hosts: A Proteomics Perspective

Seminar

11/04/10

Lily Mancour, Ph.D. Candidate, Department of Biological Chemistry, University of Michigan Medical School

3.3 Ã… Cryo-EM Structure of a Nonenveloped Virus Reveals a Priming Mechanism for Cell Entry

711 Graduate Seminar

11/09/10

Patrick J. Stover, Professor and Director of the Division of Nutritional Sciences, Cornell University

Folate-Genome Interactions: Managing Gene Expression and Genome Stability

William E.M. Lands Lectureship on the Biochemical Basis for the Physiology of Essential Nutrients

11/11/10

Stewart Cao, Ph.D. Candidate, Department of Biological Chemistry, University of Michigan Medical School

Circadian Clock-Coordinated 12 Hr Period Rhythmic Activation of the IRE1α Pathway Controls Lipid Metabolism in Mouse Liver

711 Graduate Seminar

11/16/10

Vahe Bandarian

Understanding biosynthesis of 7-deazapurines one step at a time

Seminar

11/18/10

Amber Smith, Ph.D. Candidate, Department of Biological Chemistry, University of Michigan Medical School

Regulation of Human Cytidine Triphosphate Synthetase 2 by Phosphorylation

711 Graduate Seminar

11/22/10

Heather Claxton, Ph.D. Candidate, Department of Biological Chemistry, University of Michigan Medical School
MentorDr. Janet Smith

Investigation into the Activity and Specificity of the Thioesterase II, Ketoreductase and Dehydratase Domains of Multiple Polyketide Synthases

Dissertation Defense

11/30/10

Teresa Dunn, Uniform Health Services Medical School

Serine Palmitoyltransferase: New Subunits of an Old Enzyme

Seminar

12/02/10

Jenn Gehret, Ph.D. Candidate, Department of Biological Chemistry, University of Michigan Medical School

The End of the Line: Terminal Double Bonds in Natural Products p>

Graduate Seminar

12/07/10

Joseph Reese, Penn State

Regulation of transcription elongation by mRNA decay factors and chromatin

Seminar

12/09/10

Joe Micucci, Ph.D. Candidate, Department of Biological Chemistry, University of Michigan Medical School
Mentor: Dr. David Engelke

TOPIC

711 Graduate Seminar

12/09/10

Michael Marvin, Ph.D. Candidate, Department of Biological Chemistry, University of Michigan Medical School

Identification and Characterization of Expanded RNA Binding Abilities and Cellular Roles for Nuclear RNase P

Dissertation Defense

12/14/10

David Markovitz, University of Michigan

The Exotic DEK Protein is Vital to Heterochromatin Integrity

Seminar

01/11/11

Henery Paulson, University of Michigan

The End of the Line: Terminal Double Bonds in Natural Products

Seminar

01/20/11

Noah Wolfson, Ph.D. Candidate, Department of Biological Chemistry, University of Michigan Medical School

SIRT1 Activation by Small Molecules: Kinetic and Biophysical Evidence for Direct Interaction of Enzyme and Activator

711 Graduate Seminar

01/25/11

Rene St-Arnaud, McGill University

Post-translational modification of ILK, PKA, or SUMO regulate the subcellular localization and activity of the transcriptional regulator alphaNAC in osteoblasts

Seminar

01/27/11

Swathi Krishnan, Ph.D. Candidate, Department of Biological Chemistry, University of Michigan Medical School

The program for processing newly synthesized histones H3.1 and H4

711 Graduate Seminar

02/01/11

Alexei Korennykh

Cellular Stress Response: Mechanism of Signal Propagation through Receptor Kinase/RNase Ire1

Seminar

02/01/11

Alexei Korennykh

Understanding Molecular Principles of Signal Transduction by Receptors Ire1 and RNase L

Chalk Talk

02/07/11

Cody Vild, Ph.D. Candidate, Department of Biological Chemistry, University of Michigan Medical School
Mentor: Dr. Jason Gestwicki

Conformation-specific chemical probes for amyloid-beta

Dissertation Defense

02/08/11

Greg Wang

Understanding Histone Methylation in Gene Regulation and Cell Differentiation

Seminar

02/08/11

Greg Wang

Epigenetic Regulation of Differentiation and Development: Histone Methylations and Their Effectors

Chalk Talk

02/10/11

Curtis Powell, Ph.D. Candidate, Department of Biological Chemistry, University of Michigan Medical School

Reprogramming towards pluripotency requires AID-dependent DNA demethylation

711 Graduate Seminar

02/14/11

Li Li, Ph.D. Candidate, Department of Biological Chemistry, University of Michigan Medical School
Mentor: Dr. Kun-Liang Guan

Reprogramming towards pluripotency requires AID-dependent DNA demethylation

Dissertation Defense

02/17/11

Chase Weidmann, Ph.D. Candidate, Department of Biological Chemistry, University of Michigan Medical School

A Pumilio-induced RNA structure switch in p27-3'UTR controls miR-221 and miR-222l accessibility

711 Graduate Seminar

02/24/11

Jenna Tomlinson, Ph.D. Candidate, Department of Biological Chemistry, University of Michigan Medical School

Helix Unwinding and Base Flipping Enable Human MTERF1 to Terminate Mitochondrial Transcription

711 Graduate Seminar

03/01/11

Gregory David Ph.D., New York University School of Medicine

Chromatin Modifiers in Cellular Senescence and Transformation

711 Graduate Seminar

03/08/11

Dorothy Shippen, Texas A&M

A tale of two telomerases: duplication and diversification of key components of the telomerase RNP in Arabidopsis

Seminar

03/15/11

Dorothee Kern, HHMI and Professor of Biochemistry, Brandeis University

Choreographing an enzyme's dance

G. Robert Greenberg Lectureship in Biological Chemistry

03/15/11

James L. Keck, University of Wisconsin

SSB: Central Organizer and Achilles' Heel of Bacterial Genome Maintenance

Seminar

03/29/11

Joan Broderick, Montana State University

The Radical Biochemistry of Hydrogenase Activation

Seminar

04/12/11

David Russell, Ph.D., UT Southwestern Medical Center

Oxysterols: One Precursor, Multiple Biological Roles

Seminar

04/19/11

Phyllis Hanson, M.D., Ph.D., Washington University

ESCRTs and lumenal vesicle formation in the endocytic pathway

Seminar

04/01/11

Cherisse Loucks, Ph.D. Candidate, Department of Biological Chemistry, University of Michigan Medical School
Mentor: Giorgios Skiniotis, Ph.D.

Molecular Architecture of a 40S Ribosomal Subunit Maturation Intermediate

Dissertation Defense

04/26/11

Ryan Evans, Ph.D. Candidate, Department of Biological Chemistry, University of Michigan Medical School
Mentor: Audrey Seasholtz, Ph.D.

Splicing and Multiple Binding Proteins in the Corticotropin-Releasing Hormone Stress System

Dissertation Defense

04/26/11

Joan Steitz Ph.D., Yale University

Noncoding RNAs: with a viral twist

Martha L. Ludwig Lectureship in Structural Biology

05/12/11

Dr. Beverly Davidson, Professor of Internal Medicine, Professor of Neurology, Physiology, and Biophysics, University of Iowa

Oxysterols: Emerging Therapies for Neurogenetic Disease

Distinguished Graduate Lecturer